New bone is the final step in the maturation of the product.


The presence of bone marrow indicates the ability of the product to differentiate into osteoblasts, chondrocytes, cartilage and new bone.


Osteocytes are derived from osteoblasts, or bone forming cells, and are essentially osteoblasts surrounded by the products they secreted.


Cartilage is replaced by bone during ossification in the higher vertebrates. It is indicative that the bone formation is forthcoming.


A Chondrocyte is a unique cell type in articular cartilage tissue and is essential for cartilage formation and functionality. It arises from mesenchymal stem cells.

Post sterilization in-vivo testing on each lot must demonstrate the presence of new bone, bone marrow, osteocytes, cartilage and chondrocytes within 28 days in an athymic rat model otherwise we can’t call it PentOS OI™.
In-vitro tests of PentOS OI™ have demonstrated native levels levels of BMP-2 up to 19 times the native levels in the control.

PentOs OI Max

100% Allograft Hydratable Inductive Matrix
Create your customized osteoinductive graft by combining PentOS OI™ Max, a 100% allograft Inductive Collagen Matrix (ICM) with your choice of blood, BMA, PRP, I-PRF or simply saline to form a moldable graft which
- is cell friendly,
- independent laboratory in vitro studies show to be able to maintain between 96% and 116% cell viability after 72 hours.

PENTOS OI™ Max is an osteoinductive matrix - not diluted by any carriers.

Available jar sizes: 1cc and 2.5cc


  • Mixed graft can be extruded through a syringe
  • Demonstrated Osteoinductivity
    - up to 40x native BMP vs the BMP-2 control
    - each lot histologically demonstrates all 5 elements of bone formation
  • Demonstrated Osteoconductivity
  • pH balanced – non cytotoxic
  • Shown to form bone post-sterilization in-vivo
  • Resists copious irrigation
  • 5 year shelf life at ambient storage


PentOS OI Max video

C-Graft website

PentOs OI Putty

100% Allograft DBM Putty
PentOS OI™ Putty is made from 100% human bone without any additional diluent or carriers to diminish its osteoinductive properties. EVERY lot used to manufacture PentOS OI™ products is verified
to be osteoinductive and histologically demonstrates all five elements of bone formation.
Proven to form bone. Every time. It’s that simple!


Available syringe sizes: 0.5cc, 1cc, 2.5cc and 5cc

• Verified to be osteoinductive
• Osteoconductive
• Excellent handling characteristics

  • Resists irrigation
    • Sterilized using low-dose gamma irradiation
    • Ready to use
    • Stored at room temperature

PentOS OI Flex
100% Allograft Flexible Veneer Graft

PentOS OI™ Flex is a 1 mm thick osteoinductive, demineralized cortical bone graft. When hydrated,
this veneer graft becomes pliable and easily adapts to graft sites that would be difficult to treat with particulate or putty grafts. These characteristics make PentOS OI™ Flex ideally suited for onlay
grafting for the repair of shallow bone defects or bone loss.


Available sizes: 10x10mm, 15x15mm and 17x10mm


• Pliable and adapts easily to graft sites
• Ideally suited for onlay grafting
• Can be used to augment thin or missing bone over root form implants
• Can be fixated with screws
• Sterilized using low-dose gamma irradiation
• 5 year shelf life at ambient storage

PentOS OI Sponge
100% Allograft Compressible Bone Matrix

PentOS OI™ Sponge is made of cancellous and demineralized bone, it is available as strips or blocks.

Strips: 20x10x10mm and 20x15x7mm
Blocks: 10mm³ and 12mm³


• Osteoinductive & Osteoconductive
• Hydrates in minutes
• Contours with the defect
• 5 year shelf life at ambient storage